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In general, the chirality of the orlistat analogues is important for activity.
Candidates for treatment with orlistat are patients who are obese with a body mass index a measure of obesity of more than 30 kg m2.
Orlistat, an over-the-counter anti-obesity drug, decreases absorption of dietary fat by inhibiting gastric and pancreatic lipases through covalent modification of the enzymes 7 .
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